Way 2: Re-enable Your Mouse Device via Mouse Settings If there is, you should install a new battery for your wireless mouse. And, if what you use is a wireless mouse, it is very necessary for you to check whether there is something wrong with the battery. Or you can try to plug it to another USB port on your computer to check whether the mouse pointer shows up after doing it. No matter whether you use a wired mouse or a wireless mouse, you can disconnect it first, then wait for a while and reconnect it to see if it helps. Sometimes this phenomenon occurs because your mouse is not connected properly. If your mouse cursor keeps disappearing on Windows 10, the first thing that you should do is to carefully check your mouse and the USB port. Way 1: Check the Mouse and the USB Port Carefully